Evaluation of circulating extracellular vesicles as suitable prognostic markers in MEN1-associated non-functioning pancreatic neuroendocrine neoplasia

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Introduction: Non-functioning pancreatic neuroendocrine neoplasias (NF-pNENs) significantly contribute to premature death of multiple endocrine neoplasia type 1 (MEN1) patients. Reliable prognostic markers for disease progression are lacking. Circulating liquid biomarkers, including microRNAs and Long-non-Coding (LnC) RNAs in extracellular vesicles, are emerging as new prognostic tools.

Aim(s): The aim of this study was to analyse the course of disease in MEN1-associated NF-pNEN, and exploring the predictive value of exosomal-miRNA 451a (exo-miR451a) and exosomal LnC-RNA NEAT1, located on the MEN1 gene.

Materials and methods: Patient characteristics, treatment, and NF-pNEN progression were assessed for aggressiveness, defined by rapid tumor growth or metastatic disease or new relevant lesions. Exo-miR-451a and exo-LnC-RNA NEAT1 serum expression were quantified using RT-qPCR and correlated with clinical data.

Conference:

Presenting Author:

Authors: Manoharan J, Khizanishvili N, Krasser-Gercke N, Albers M, Mintziras I,

Keywords: Multiple endokrine neoplasia type 1, Extracellular vesicles, Non-functioning pancreatic neuroendocrine neoplasia, exosomal-LnC-RNA NEAT1, exosomal miRNA451a,