Evaluation of Helicobacter pylori proteins in the pathogenesis of type 1 gastric neuroendocrine tumor and urticaria. In-silico approach

#3358

Introduction: Helicobacter pylori (Hp) has been linked to several diseases such as chronic spontaneous urticaria (CSU), gastritis, and type 1 gastric neuroendocrine tumors (T1-GNET). Although these diseases seem to have different mechanisms, their relationship with Hp suggests a possible common inflammatory pathway.

Aim(s): To identify potential cross-reactive antigens between Hp (strain 26695) and humans involved in CSU and in T1-GNET.

Materials and methods: Alignment were carried out among human proteins associated with CSU (9 proteins) inflammation, T1-GNET (32 proteins), and Hp proteome. We performed pairwise alignment among the human and Hp antigens with PSI-BLAST. Modelling based on homology was done with the Swiss-model server and epitope prediction with the Ellipro server. Epitopes were located on a 3D model using Pymol software.

Conference:

Presenting Author:

Authors: González Devia D, Sánchez Caraballo A, Guzman Ruiz Y, Sanchez Caraballo J, Múnera Gomez M,

Keywords: autoimmune gastritis, urticaria, in-silico analysis, type 1 gastric neuroendocrine tumor,