Expression and Clinical Significance of Alpha-internexin in Gastroenteropancreatic Neuroendocrine Neoplasm

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Introduction: Alpha-internexin is a 66-kDa neuronal intermediate filament protein, data on its role in gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) are limited.

Aim(s): To explore the expression and the epigenetic regulation mechanism of α-internexin in GEP-NEN and investigate its clinical significance.

Materials and methods: α-internexin was detected by immunohistochemistry in 286 GEP-NEN specimens. The methylation of α-internexin promoter was evaluated by bisulfite genomic sequencing.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Jie C

Authors: Yuhong W, Yuanjia C, Minhu C, Jie C,

Keywords: gastroenteropancreatic neuroendocrine neoplasm, alpha-internexin, prognosis, methylation,