Expression of Somatostatin Receptors and Dopamine 2 Receptor in Lung Carcinoids as a Possible Biotherapy Target


Introduction: Expression of somatostatin receptors (SSTRs) and dopamine 2 receptor (D2R) in neuroendocrine tumors is of clinical importance, as somatostatin analogues and dopamine agonists are used in biotherapy.

Aim(s): To examine the expression of the five SSTR subtypes and D2R in lung carcinoids (LCs).

Materials and methods: Tumor specimens from 87 patients with primary LCs (typical n=73, and atypical n=14) were included. The expression of all SSTR subtypes and D2R was evaluated immunohistochemically, and statistically correlated to tumor type. The tumors were considered positive if receptor immunoreactivity appeared in the majority of the tumor cells.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Kanakis G, Grimelius L, Trigidou R, Kaltsas G, Tsolakis A,

Keywords: somatostatin receptor subtypes, dopamine receptor 2, lung carcinoids,

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