FDG-PET is Superior to WHO Grading in Predicting Overall Survival of Patients with Neuroendocrine Tumors: A Prospective Study of 172 Patients

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Introduction: Accurate grading of patients with neuroendocrine tumors (NETs) is essential for risk stratification and optimal choice of therapy. Currently, WHO grading is based on histo-pathologically assessed degree of tumor proliferation.

Aim(s): To assess the prognostic value of FDG-PET imaging for risk stratification of NETs and compare it with WHO grading.

Materials and methods: We conducted a prospective, single-center cohort study evaluating the prognostic value of FDG-PET imaging and compared it to the current WHO grading. Patients (n = 172) of all grades and with histologically confirmed NETs of gastroenteropancreatic or pulmonary origin were enrolled. The primary end point was overall survival (OS). Progression-free survival (PFS) was a secondary end point.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Kjaer A

Authors: Binderup T, Johnbeck C, Loft A, Berthelsen A, Federspiel B,

Keywords: PET, PET/CT, imaging, survival,