FIT-NETs: Assessing the effects of an exercise programme on the physical and emotional well-being of patients with advanced G1-2 NETs of GEP or unknown origin

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Introduction: Physical activity programs in solid tumours have shown to improve symptom control and even survival, but their impact on NENs remains unexplored. Advanced disease, systemic therapy, and hormonal secretion in these tumours often lead to muscle wasting and sarcopenia.

Aim(s): To implement a physical exercise training programme to enhance musculoskeletal health, cardiorespiratory fitness, and overall well-being in NET patients.

Materials and methods: This study enrolled patients with advanced G1-2 GEP/UK-primary NETs receiving systemic therapy, PS of 0-1 and no major cardiorespiratory comorbidities. The intervention consisted of a physical exercise programme based on the Cardiac Rehabilitation Society (SORECAR) protocol, supervised by a physiotherapist and adapted to patient’s condition. Impact on lung capacity, sarcopenia, and QoL were assessed at baseline, 3 & 6 months through the following procedures: 1) blood tests and a cytokine panel; 2) maximal inspiratory and expiratory pressures (MIP & MEP); 3) ultrasound to measure quadriceps vastus medialis diameter; 4) CT scan to assess psoas muscle area; and 5) EORTC QLQ-C30 and QLQ-GINET21 questionnaires.

Conference:

Presenting Author: Anton-Pascual B

Authors: Anton-Pascual B, Rodriguez-Gomez J, de Cima A, Herrero-Llorente A, Modrego A,

Keywords: FIT-NET, physical exercise program, Quadriceps, MEP & MIP, QoL,