Gallium-68 DOTANOC PET/CT in locally advanced/metastatic WHO grade 2 gastroenteropancreatic neuroendocrine tumors – Clinical and prognostic impact in assessing progression free survival

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Introduction: Ga-68 DOTANOC PET/CT based prognostic factors can help in risk-stratification of patients with locally advanced/metastatic GEP-NETs.

Aim(s): The study aimed at evaluating prognostic role of Ga-68 DOTANOC PET/CT parameters in assessing progression free survival (PFS) in patients with grade II GEP-NETs.

Materials and methods: This retrospective study included 85 patients with WHO grade II GEP-NETs who underwent Ga-68 DOTANOC PETCT. Patients were stratified into two groups based on median SUV max of target lesion, liver involvement on DOTANOC scan (Krennings 3/4) and primary resection. Receiver operating characteristics curve (ROC) derived an optimal cut-off. Progression free survival was calculated from the date of DOTANOC PETCT to date of clinical/radiological progression or death due to disease. Survival analysis was based on Kaplan Meier method and was compared using log rank test.

Conference:

Presenting Author:

Authors: Dev I, Rangarajan V, Purandare N, Agrawal A, Shah S,

Keywords: Ga-68 DOTANOC, PET/CT, Grade 2 NET, SUVmax, liver involvement,