Genotype – Phenotype Correlations and Timing of Prophylactic Thyroidectomy in Patients with Familial Medullary Thyroid Carcinoma

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Introduction: Recommendations on the timing of prophylactic thyroidectomy (PTTE) in patients with familial medullary carcinoma (FMTC) are based on classification of RET mutations into four risk levels (ATA 2009).

Aim(s): To study the clinical course of FMTC patients with various RET mutations operated with a time delay against recommended timing.

Materials and methods: Retrospective analysis of clinical course in 42 RET mutation carriers from 12 FMTC and MEN 2A families.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Podoba J

Authors: Podoba J, Podobová M, Grigerová M, Weismanová E, Závodná K,

Keywords: familial medullary carcinoma, prophylactic thyroidectomy, timing,