Grade 2 (G2) gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs): Risk stratification beyond Ki-67?

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Introduction: G2 GEP-NETs are well-differentiated neuroendocrine neoplasms with Ki-67 proliferation index of 3-20%. Rather than behaving as a monolithic category, these neoplasms are often characterized by an unpredictable outcome, and additional biomarkers are needed.

Aim(s): To analyze G2 GEP NETs, identifying possible prognostic/predictive factors.

Materials and methods: We retrospectively analyzed the clinicopathological features of 142 G2 GEP-NET, diagnosed and treated in our institution from 2011 to 2022, with available histopathological material and complete clinical records. A histopathological review was performed according to WHO ENDO5.

Conference:

Presenting Author:

Authors: Laffi A, Zerbi A, Lavezzi E, Carrara S, Rossi E,

Keywords: GEP NET, G2, neuroendocrine tumor, neuroendocrine,