High expression of ADAM15 in non-functional pancreatic neuroendocrine tumors is associated with high-density tumor-infiltrating neutrophils and predicts poor outcome

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Introduction: Non-functional pancreatic neuroendocrine tumors (NF-PanNETs) displayed heterogeneous prognoses. Copy number variations (CNVs) of ADAM15 significantly increased in patients who underwent postoperative early recurrence. ADAM15 (a disintegrin and metalloproteinase 15) has been identified as a key molecule in progression and metastasis of many tumors, regulating immune infiltration. However, correlation between ADAM15 and NF-PanNETs remains unknown.

Aim(s): This study aims to investigate prognostic role of ADAM15 in NF-PanNETs and develop a novel risk stratification model to predict postoperative recurrence and metastasis of NF-PanNETs.

Materials and methods: We analyzed clinicopathlogical features of 115 patients with primary NF-PanNETs and 35 patients with liver metastases. Immunohistochemistry and immunofluorescence were utilized to examine the expression of ADAM15 and immune infiltration. Recurrence-free survival (RFS) and overall survival (OS) were evaluated using Cox regression.

Conference:

Presenting Author:

Authors: Tang L, Ying Y, Peng M, Wang Y, Lou W,

Keywords: pancreatic neuroendocrine tumor, recurrence, metastasis, ADAM15, tumor-infiltrating neutrophils,