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High Grade (G3) Gastro-Entero-Pancreatic Neuroendocrine Neoplasms: Should the New WHO Classification Apply to All?

#2248

Introduction: Grade 3 (G3) neuroendocrine neoplasms (NEN), arising from the gastro-entero-pancreatic system (GEP), are classified according to WHO 2010 and defined as having a Ki67 of > 20%. However this groups together G3 well differentiated neuroendocrine tumours (WD-NET) with poorly differentiated neuroendocrine carcinomas (PD-NEC). Recently, WHO have proposed a new classification for pancreatic NEN, with sub-division into G3 WD-NET and G3 PD-NEC

Aim(s): To evaluate each sub-group of this new classification and determine whether it should be extended to apply to all G3 GEP-NENs

Materials and methods: We retrospectively identified all G3 GEP NENs from our patients' database. Histopathological reports were analysed and patients were divided into G3 WD-NETs or G3 PD-NECs. Patients' demographics, imaging data and response to treatment was analysed from electronic records

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Furnace M

Authors: Furnace M, Muller G, Rundell C, Shah R, Luong T,

Keywords: G3, well-differentiated, poorly differentiated, Ki-67,

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