High prevalence of deficiencies in fat-soluble vitamins, minerals and trace elements but no relation with malnutrition in patients with gastroenteropancreatic neuroendocrine tumors using somatostatin analogues

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Introduction: Since 2019 the Global Leadership Into Malnutrition (GLIM) criteria exist for diagnosing malnutrition. Patients (pts) with gastoenteropancreatic (GEP) neuroendocrine tumors (NETs) treated with somatostatin analogues (SSAs) are at risk of malnutrition. Deficiencies in fat-soluble vitamins, minerals and trace elements (micronutrients) are not part of the GLIM criteria but frequently reported in pts with GEP-NETs treated with SSAs.

Aim(s): To describe the prevalence of deficiencies in micronutrients and explore the relation of deficiencies with malnutrition in pts with GEP-NETs treated with SSAs.

Materials and methods: A cross-sectional study was performed screening single-time pts with GEP-NETs treated with SSAs for deficiencies in fat-soluble vitamins (A, D3), minerals (magnesium, iron), trace elements (zinc) and for malnutrition using GLIM criteria. This included weight loss, body mass index (BMI) and sarcopenia using body composition analysis.

Conference:

Presenting Author: Clement D

Authors: Clement D, van Leerdam M, Tesselaar M, Cananea E, Martin W,

Keywords: gastroenteropancreatic neuroendocrine tumor, somatostatin analogue, malnutrition, sarcopenia, survival,