Histological Differentiation Provides Useful, Additive and Independent Prognostic Information to Proliferation Index in G2 and G3 Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)


Introduction: The WHO 2010 classification has provided a valuable tool to stratify NEN prognosis based on an objective measure, the proliferation index. However, morphology and, in particular, tumor differentiation, is emerging again as a relevant feature that should not be dismissed due to its important clinical implications.

Aim(s): To assess the prognostic impact of histological differentiation within WHO 2010 G1/G2/G3 categories.

Materials and methods: 1456 out of 2906 patients with GEP-NENs registered in RGETNE met eligibility criteria and were analyzed. Eligible cases must had been typified both by the proliferative index (Ki-67 <3%, 3-20%, > 20%), and by histological differentiation (well differentiated tumors – NETs - or poorly differentiated carcinomas - NECs). The Wilcoxon test was used to compare survival data.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: García Carbonero R

Authors: Sánchez Cánovas M, Nuñez B, Benavent M, Teulé A, Segura A,

Keywords: WHO 2010 classification,

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