Histopathological Revision for Gastroenteropancreatic Neuroendocrine Neoplasms in Expert Centers: Does It Make the Difference?

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Introduction: A proportion of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) referred to NEN expert centers need a histopathological revision.

Aim(s): To describe the clinical impact of histopathological revision for referred GEP-NEN patients.

Materials and methods: Retrospective multicenter analysis including all GEP-NENs receiving a histopathological revision required by the institutional tumor boards of 7 European NEN expert centers (Jan 2016‒Dec 2016). Primary endpoint: to evaluate the impact of histopathological revision on patient management (indication to new medical treatment, to surgery, to further imaging tests). Secondary endpoint: to describe the changes in the histopathological diagnosis. The study was developed by the "Knowledge Network" Group. The histopathological revision was performed by a "Histopathology Consortium", including the pathologists with an experience in the NET field at each site.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Merola E

Authors: Merola E, Zandee W, de Mestier L, Klümpen H, Geboes K,

Keywords: neuroendocrine, NET referral centers, histopathological revision, patient management,