Identification of IRS2 as a prognostic and therapeutic target in gastrointestinal neuroendocrine tumours

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Introduction: Intestinal neuroendocrine tumours (INETs) are rare malignancies characterised by diverse clinical outcomes. In our previous research, high expression of IRS2 was associated with poor prognosis in gastric neuroendocrine tumours, but its role in intestinal neuroendocrine tumours remains unclear.

Aim(s): This study aims to elucidate the expression of IRS2 in INETs and its association with clinical outcomes while also exploring its biological functions in tumour progression.

Materials and methods: We first selected 40 clinical specimens to evaluate the expression of IRS2 and its association with prognosis. Then, gene silencing and overexpression techniques were utilised to assess the role of IRS2 in cell proliferation, migration, invasion, and apoptosis of INETs cells lines. Additionally, transcriptome sequencing of IRS2 knockdown and control groups was conducted to identify relevant signalling pathways, which were validated using Western blotting and pathway inhibitors.

Conference:

Presenting Author:

Authors: Zhang M, Li S,

Keywords: gastrointestinal neuroendocrine tumour, IRS2, tumour progression,