Impact of chromogranin A expression on clinicopathological characteristics and prognosis in patients with gastrointestinal tumours exhibiting neuroendocrine differentiation

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Introduction: Pathological diagnosis of neuroendocrine differentiation (NED) relies on histomorphological assessment and specific markers, including chromogranin A (CgA) and synaptophysin (Syn). Previous studies indicate that tumours with a high proportion of CgA (+) exhibit increased malignancy and aggressiveness in neuroendocrine tumours, suggesting that CgA may serve as a prognostic marker.

Aim(s): This study aims to examine the influence of CgA expression on the clinicopathological characteristics and prognosis of gastrointestinal adenocarcinoma with NED.

Materials and methods: This study examines patients (recruited 2018-2022) with gastrointestinal adenocarcinoma exhibiting NED treated at our hospital. Clinical, histopathological, and prognostic data were collected to compare the clinicopathological characteristics and prognosis of patients with CgA(+) and CgA(-) gastrointestinal adenocarcinoma with NED.

Conference:

Presenting Author: Liang T

Authors: Wang W, Jiang K, Liu X, Zhao L, Yu Z,

Keywords: neuroendocrine differentiation, gastric cancer, colorectal cancer, chromogranin A,