Impact of Multimodal Perioperative Treatment in Patients with Resected Non-Metastatic Grade 3 Neuroendocrine Neoplasms (NEN G3)
Introduction: Patients with grade 3 neuroendocrine neoplasm (NEN G3) have a limited prognosis. Even in a non-metastatic stage, the risk of recurrence after surgery is high. Multimodal perioperative treatment, including chemotherapy and/or radiotherapy in an adjuvant or neoadjuvant setting, has improved the prognosis in numerous tumor entities; however, it has not been systematically evaluated in NEN G3 so far. Nevertheless, perioperative chemotherapy is generally recommended in most current treatment guidelines for NEN G3.
Aim(s): To analyze the impact of multimodal perioperative treatment on the prognosis of resected NEN G3 patients.
Materials and methods: Retrospective analysis of all patients in the NEN database of our center with non-metastatic NEN G3 who received surgery of the primary tumor between 03/2011 and 11/2019.
Conference: 17th Annual ENETSConcerence (2020)
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