Impact of primary tumor resection and metastasectomy among gastroenteropancreatic neuroendocrine tumors with liver metastases only on survival

#3703

Introduction: The incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is increasing globally, and the patients are often diagnosed with synchronous liver metastases. Despite recommendations for primary tumor resection (PTR) with or without liver resection (LR) in the patients, there are conflicting data for their impact on overall survival (OS).

Aim(s): We aimed to determine the impact of PTR and LR on OS for patients with GEP-NETs and liver metastases only.

Materials and methods: Patients with GEP-NETs and liver metastases only diagnosed between 2016 and 2018 were identified from the National Cancer Database. Multiple imputations were used to accommodate missing data, and inverse probability of treatment weighting (IPTW) was conducted to minimize bias. Survival analyses were performed with IPTW-adjusted Kaplan-Meier curves and Cox proportional hazards regression models.

Conference:

Presenting Author: Chen Q

Authors: Chen Q, Li K, Rhodin K, Bartholomew A, Lidsky M,

Keywords: Gastroenteropancreatic neuroendocrine tumor, Liver metastasis, Resection, Prognosis, National Cancer Database,