Increase of the Ki67 Proliferation Index over Time in Patients with Neuroendocrine Neoplasms

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Introduction: Whether the Ki67 index increases over time in relation to progression is scarcely studied.

Aim(s): We investigated if Ki67 increased in patients with confirmed progressive disease.

Materials and methods: Thirty-five patients (21 men) with a median (range) age of 60 (39-76) years and a Ki67 < 20% at diagnosis and an increase of ≥8% at progression were included. The Ki67 was determined in hot spot areas either in surgical specimens or core biopsies from primary tumor or metastases at diagnosis and at progression evaluated by CT or SRI.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Holmager P, Langer S, Federspiel B, Andreassen M, Kjær A,

Keywords: neuroendocrine, Ki67, progression,