Indocyanine green fluorescence guided resection of neuroendocrine liver metastases: A proof-of-concept study

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Introduction: Even though the relative indolent character of neuroendocrine neoplasms, untreated NELM have a detrimental impact on survival outcomes. Therefore, complete resection is recommended if technically possible.

Aim(s): The aim of this study was to assess the value of indocyanine green (ICG) guided fluorescence guided surgery of neuroendocrine liver metastases.

Materials and methods: This is a proof-of-concept study including patients who underwent resection for NELM of any grade, and patients who underwent liver resection for other tumor types to compare ICG uptake. Patients received an intravenous bolus of 10 mg ICG approximately 24 hours prior to surgery. Localization and resection margins of liver metastases were assessed with intra-operative ultrasonography and by fluorescence signal pattern. All resected lesions underwent histopathological assessment by an expert pathologist.

Conference:

Presenting Author: Kaçmaz E

Authors: Kaçmaz E, Slooter M, Tanis P, Nieveen van Dijkum E, Swijnenburg R,

Keywords: neuroendocrine liver metastasis, fluorescence guided surgery, indocyanine green,