Influence of pathogenic somatic mutations on the survival rates of patients with neuroendocrine tumors of the gastrointestinal tract (NET GI)

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Introduction: Genomic sequencing of 40 tumors samples from patients diagnosed with NET GI was performed. Further, according to the results obtained, the survival rates of patients were evaluated.

Aim(s): To assess the impact of pathogenic somatic mutations on the survival rates of patients with NET GI.

Materials and methods: In 9 samples out of 40, pathogenic mutations were detected. In the studied samples there were such mutations as PTEN (2.5%) (+BRCA1), PIK3CA (2.5%), RB1 (2.5%) (+BRCA2), CHEK2 (2.5%) (+POLE), MLH1 (2.5%) (+BRCA1), t790m (2.5%) (+BRCA1). The most frequent mutations were BRCA1 (7.5%) and BRCA2 (7.5%).

Conference:

Presenting Author: Androsova A

Authors: Androsova A, Orlova R, Gordiev M, Ivanova A, Belyak N,

Keywords: NET, mutations, BRCA, POLE, Genomic sequencing,