International Multicentre Retrospective Study on the Safety of Radioembolization with Yttrium-90 Resin Microspheres after Systemic Radionuclide Therapy in Neuroendocrine Tumors

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Introduction: In the treatment metastatic neuroendocrine tumours (mNET) safety concerns exist when treating patients with radioembolization (RE) after prior systemic radionuclide therapy (SRT)

Aim(s): The aim of this study was to assess safety and efficacy of yttrium-90 resin microspheres RE in mNET after prior systemic radionuclide therapies (SRT).

Materials and methods: Patients treated with SRT before RE and with at least baseline and follow-up CT/MRI imaging after 3 months were included. Clinical, laboratory, and imaging parameters were retrospectively collected. Efficacy was based on imaging response according to RECIST 1.1 (liver-only) and clinical response. Biochemical toxicity data was based on Common Terminology Criteria for Adverse Events (CTCAE) v4.03.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Braat A

Authors: Braat A, Kappadath C, Ahmadzadehfar H, Stothers C, Deroose C,

Keywords: PRRT, Radioembolization, neuroendocrine tumors, metastasis, radionuclide treatments,