Intra-individual comparison of 68Ga-DOTATATE PET/CT and PET/MR

#3814

Introduction: Somatostatin receptor (SSTR) PET is a cornerstone of modern NET management and is used for (re)staging and PRRT selection. Next to PET/CT, hybrid PET/MR is now available for hybrid imaging of NETs.

Aim(s): To investigate whether CT or MR with diffusion-weighted sequence, is the best hybrid partner for 68Ga-DOTATATE PET. The best hybrid partner was defined as the one with the highest concordance rate of PET findings, as double confirmation of lesions on two different imaging modalities increases the likelihood that these lesions are malignant, avoiding the need for additional imaging.

Materials and methods: This monocentric, prospective study included patients who received a same-day 68Ga-DOTATATE PET/CT and subsequent PET/MR, for suspicion of NET, (re)staging or PRRT-selection. Concordance of detection of malignant lesions in an organ was measured between PET and CT, and PET and MR. The number of malignant lesions were categorised in bins (ordinal variable): 0, 1, 2-5, 6-10, 11-20, >20 countable and diffuse/uncountable. The difference in number of malignant lesions was obtained as the difference in bin level between PET and CT, and PET and MR with a Δbin closer to zero implying a higher concordance rate.

Conference:

Presenting Author:

Authors: Ahmadi Bidakhvidi N, Lens G, Vandecaveye V, Grauwels S, Deckers W,

Keywords: 68Ga-DOTATATE, PET/CT, PET/MR,