Liver Resection for Neuroendocrine Tumors Liver Metastases in Transplantable Patients within the Milan Criteria

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Introduction: Liver transplantation (LT) has been prosed as a curative treatment for metastatic gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) but there is a lack of consensus on its real benefit when compared with hepatectomy.

Aim(s): We sought to analyze survival outcomes of patients undergoing liver resection for GEP-NETs liver metastasis (NELM) according to the Milan Criteria proposed to select patients with GEP-NET candidate to LT.

Materials and methods: A multicentric database including seven tertiary referral centers was used to identify patients submitted to hepatectomy for NELM between January 1990 and December 2014. We identify patients fulfilling Milan Criteria: well-differentiated NET (Ki-67<10%), age <60 years, no extrahepatic disease, primary NET resected, stable disease for >6 months, and <50% liver involvement (Group 1). Extended Milan Criteria included patients up to 70 years age old (Group 2). Recurrence after liver surgery was treated according to international guidelines. No patients underwent liver transplantation during the follow-up

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Ruzzenente A

Authors: Ruzzenente A, Bagante F, Aldrighetti L, Ercolani G, Giuliante F,

Keywords: Surgery, Liver Metastases, Hepatectomy,