Loss of protein expression of tumor suppressor genes in neuroendocrine tumors – A tissue microarray analysis of 201 tumors from various organ sites

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Introduction: Neuroendocrine tumors (NET) are a heterogenous group of tumors which differ in outcome based on their primary site. So far, data on inactivation of tumor suppressor genes in NET are mainly based on pancreatic and small intestine NET (pNET, siNET), whereas NET from other organ sites have not rigorously been analysed.

Aim(s): The aim of this study is to analyse the loss of tumor suppressor genes in various NET primaries.

Materials and methods: We analysed a tissue microarray comprising n=201 individual NET from various primaries, including pNET (n=48), siNET (n=47) as well as NET from colon (n=6), rectum (n=2), appendix (n=14), stomach (n=5) and lung (n=12). Protein expression of the tumor suppressor genes DAXX, ATRX and p27 was evaluated immunohistochemically and correlated with collected clinical data, e.g. age, sex, TNM status, UICC stage, overall survival (OS) and progression-free survival (PFS).

Conference:

Presenting Author:

Authors: Amin T, Viol F, Fründt T, Krause J, Fraune C,

Keywords: TMA, DAXX/ATRX, tumor suppressor, neuroendocrine tumor,