Loss of Succinate Dehydrogenase (SDHB) Expression in Midgut Carcinoids as Prognostic Factor: a New Marker of Personalized Cancer Medicine in Neuroendocrine Tumors?
Introduction: Gene mutations of SDH complex have been involved in the pathogenesis of cancer cells. These mutations are often associated with loss of activity of SDH subunity B and overexpression of HIF-1a, which play a central role in angiogenesis.
Aim(s): To investigate the expression of SDHB levels in carcinoids as prognostic marker.
Materials and methods: 31 carcinoid tumors were analyzed. Immunoistochemical (IHC) results for SDHB were assessed according to the staining intensity scored as 1 (low) or 2 (high).
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