Management of Multiple Endocrine Neoplasia Type 1 in Patients with Pancreatic Neuroendocrine Tumors

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Introduction: Screening for MEN-1 is an integral part of examination of patients with pNETs because revelation of this hereditary pathology radically influences tactics of treatment.

Aim(s): To analyze management of MEN-1

Materials and methods: Data on 46 patients (m-10, w-36) with MEN 1 syndrome was analyzed. In this group of patients we revealed pituitary adenomas in 59 % (N=27), primary hyperparathyroidism in 78 % (N=36) and pNETs in 94 % (N=43). There were 39 insulinomas, 7 nonfunctioning tumors, 4 gastrinomas and 2 glucagonomas. We used clinical, hormonal and a complex of imaging procedures of the pituitary, parathyroid and pancreas, supplemented by arterial stimulated venous blood sampling.

Conference:

Presenting Author:

Authors: Vasiliev I, Egorov A, Musaev G, Kondrashin A, Gurevich L,

Keywords: MEN-1 syndrome, pancreatic neuroendocrine tumor,

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