MEN1 Syndrome with Pancreatic Involvement and Synchronous Lung Adenocarcinoma: A Case Report

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Introduction: Lung lesions in MEN1 patients makes us consider firstly a neuroendocrine tumor (NET) as carcinoids are part of MEN1 syndrome.

Aim(s): To report the clinical and pathological features of a patient with synchronous MEN1 syndrome with both pulmonary carcinoid and adenocarcinoma.

Materials and methods: A 66 years old male, belonging a MEN 1 family and with previous antrectomy for duodenal ulcer, was observed for persistent epigastric pain. Laboratory findings were consistent with Zollinger-Ellison syndrome and hyperparathyroidism. CEA was slightly elevated. Abdominal CT-scan showed a 6 cm hypervascular mass in the body of the pancreas positive to Octreoscan scintigraphy, while FDG-PET demonstrated hypermetabolism in the pancreas and the right lung in an area of 2.6 cm confirmed by thoracic MRI, with mediastinal pleura involvement. The patient underwent a right superior lobectomy. Histology reported acinar adenocarcinoma (T3N1G3) coexisting with 1 cm carcinoid with one positive lymphnode. Three months later he underwent a spleen-distal pancreatectomy, subtotal parathyroidectomy and duodenal tumor excision.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Liço V, Milanetto A, Alaggio R, Pedrazzoli S, Pasquali C,

Keywords: men1,