Mesenteric fibrosis in small intestinal neuroendocrine tumors (SI-NETs) – Steps towards understanding its pathogenesis

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Introduction: Mesenteric fibrosis (MF) occurs in 50% of patients with SI-NETs, causing significant morbidity and mortality. The pathogenesis of MF in SI-NETs is incompletely understood with no biomarkers or radiological criteria to predict long-term complications of SI-NET associated MF.

Aim(s): To research potential molecular markers of MF, using tissue and blood RNA sequencing, understanding the concept of the fibrosome and assessing epigenetic factors.

Materials and methods: RNA sequencing and gene set enrichment analysis (GSEA) was performed on tissue collected from a cohort of 46 SI-NET patients including normal SI (n=46), primary tumor (PT) (n=40) and mesenteric metastases (MM) (n=38). Patients were grouped into four groups of MF severity based on radiological, surgical and histological assessments. qPCR was performed using NETest-Fibrosome markers CTGF, CD59, APLP2, FZD7, BNIP3L previously detected in SI-NET blood.

Conference:

Presenting Author:

Authors: Hodgetts H, Martins M, Luong T, Hall A, Thirlwell C,

Keywords: small, intestine, neuroendocrine tumor, fibrosis, mesenteric, rna-sequencing, biomarker,