Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract. ARGENTUM Group


Introduction: Mixed adenoneuroendocrine carcinomas of the gastrointestinal tract are rare neoplasms. In the 2000 WHO classification of endocrine tumors, such neoplasms were defined as mixed exocrine-endocrine tumors when each component represents at least 30% of the lesion. In the most recent WHO classification, such neoplasms are called “mixed adenoneuroendocrine carcinomas” (MANECs). They are a challenge for the diagnostic and treatment.

Aim(s): To evaluate the clinical and histopathological characteristics of MANECs.

Materials and methods: We review all cases of MANECs of database Argentum group. The MANEC diagnosis was confirmed by conventional histopathology on surgical specimen. Ki-67 analysis was done on paraffin-embedded sections using immunohistochemistry. Grading was according to ENETS recommendations.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Cabanne A, Bestani C, Pesce V, O'Connor J, Kujaruk M,

Keywords: MANEC, NETs,

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