Mixed Urothelial and Neuroendocrine Carcinoma of the Urinary Bladder: Case Report and Literature Review

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Introduction: Neuroendocrine tumors (NETs) comprise

Aim(s): The present case highlights the importance of immunohistochemistry in arriving at an accurate diagnosis, and discuss therapeutic options and prognosis.

Materials and methods: A 66-year-old male patient presented to hospital with hematuria.US showed a suspicious mass in the urinary bladder.CT revealed lobulated mass along the left lateral wall of the bladder.Cystoscopy revealed a large broad-based tumor in the bladder.A transurethral resection of the tumor was performed.Histopathological examination revealed a tumor composed of 2 different components.The major component corresponded to urothelial carcinoma.The other tumor component was composed of small cell NEC.Immunohistochemical analysis revealed a positive staining result for synaptophysin,CD 56,and a negative staining result for Chromogranin.Ki67 was about 30%.A complete gastrointestinal endoscopic evaluation and CT were normal.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Saidi M, Ghomari S,

Keywords: urinary bladder, mixed tumor, urothelial carcinoma, neuroendocrine carcinoma, chemotherapy, radiotherapy,