Mixed Urothelial and Neuroendocrine Carcinoma of the Urinary Bladder: Case Report and Literature Review


Introduction: Neuroendocrine tumors (NETs) comprise <1% of all bladder tumors,characterized by poor prognosis. These tumors may be either pure or impure, intermixed with urothelial carcinoma. There is currently no therapeutic consensus. We report the case of primary impure neuroendocrine carcinoma (NEC).

Aim(s): The present case highlights the importance of immunohistochemistry in arriving at an accurate diagnosis, and discuss therapeutic options and prognosis.

Materials and methods: A 66-year-old male patient presented to hospital with hematuria.US showed a suspicious mass in the urinary bladder.CT revealed lobulated mass along the left lateral wall of the bladder.Cystoscopy revealed a large broad-based tumor in the bladder.A transurethral resection of the tumor was performed.Histopathological examination revealed a tumor composed of 2 different components.The major component corresponded to urothelial carcinoma.The other tumor component was composed of small cell NEC.Immunohistochemical analysis revealed a positive staining result for synaptophysin,CD 56,and a negative staining result for Chromogranin.Ki67 was about 30%.A complete gastrointestinal endoscopic evaluation and CT were normal.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Saidi M, Ghomari S,

Keywords: urinary bladder, mixed tumor, urothelial carcinoma, neuroendocrine carcinoma, chemotherapy, radiotherapy,

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