Molecular biological mechanisms of Qizhen Yiliu decoction (QZYL) for treatment of pancreatic neuroendocrine tumors (pNETs) based on liquid chromatography-mass spectrometry (LC-MS) integrated network pharmacology

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Introduction: Our previous studies indicated that the Chinese medicine compound QZYL could prolong the postoperative recurrence-free survival of patients with pNETs as adjuvant therapy, but the molecular biological mechanism of its action is still unclear.

Aim(s): To investigate the core chemical composition of QZYL and to predict its molecular biological mechanism in the treatment of pNETs.

Materials and methods: LC-MS was used for the analysis of the chemical composition of the QZYL, and the protein-protein interaction network was constructed by target genes co-related to chemical composition and pNETs collected in databases like TCMSP, Genecards, etc. The molecular docking models were used to validate the interactions of key chemical components with core targets.

Conference:

Presenting Author: Cheng Z

Authors: Cheng Z, Yu F, Tan H,

Keywords: Pancreatic neuroendocrine tumor, traditional Chinese medicine, network pharmacology, target gene prediction,