Molecular mechanism of curcumin inhibiting proliferation of pancreatic neuroendocrine tumor cells

#3596

Introduction: Studies have shown that curcumin regulates malignant tumors through many important signalling pathways, such as Ras, P13K, p53, AKT, mTOR, Wnt-catenin, etc. Regarding the research on the molecular target mechanism of curcumin inhibiting pancreatic neuroendocrine tumors, there is a lack of relevant data at home and abroad. The proven antitumor potential targets of curcumin were intersected with the proteins present in pancreatic neuroendocrine tumor QGP-1 cells, and AKT/mTOR was selected as the central content of this study.

Aim(s): To study how curcumin regulates related proteins or pathways to interfere with the proliferation of pancreatic neuroendocrine tumor cells.

Materials and methods: Western Blot method was used to observe the expression of curcumin on AKT/mTOR pathway in pancreatic neuroendocrine tumor QGP-1 cells.

Conference:

Presenting Author: Han D

Authors: Han D, Du H,

Keywords: Curcumin, Pancreatic neuroendocrine tumor cells, Mechanism,