Molecular typing and mutational characterisation of rectal neuroendocrine neoplasms

#3948

Introduction: Rectal neuroendocrine neoplasms (NENs) are rare neoplasms with limited understanding of its genomic alterations and molecular typing.

Aim(s): The differences of mutated genes and signaling pathways in different pathological grades and metastatic / non-metastatic groups were compared. It helped to search for potential targets.

Materials and methods: The paraffin-embedded tissue specimens of 38 patients with rectal NENs after surgery were subjected to whole gene sequencing (WGS), and mutation profilings were drawn to identify molecular types.

Conference:

Presenting Author:

Authors: Duan X, Yin F,

Keywords: rectal neuroendocrine neoplasms, genomic alterations, molecular typing, signaling pathway, DDR mutant genes,