Multifunctional gold nanorods @iron-based metal-organic framework for magnetic resonance imaging guided photothermal therapy in pancreatic neuroendocrine tumor

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Introduction: Pancreatic neuroendocrine tumor lacks effective treatment options and leads to poor prognosis. Photothermal therapy (PTT) is a promising strategy for tumor treatment. Until now, the fabrication of multifunctional photothermal agents is vital importance and still of great urgency for effective PTT generally.

Aim(s): In this work, novel Au nanorods @ iron-based metal-organic framework (AuNR@MIL-100) are successfully fabricated for magnetic resonance imaging (MRI) guided PTT in pancreatic neuroendocrine tumor.

Materials and methods: The AuNR@MIL-100 was firstly prepared by a layer-by-layer technique. The AuNR@MIL-100 was characterized by measuring X-ray photoelectron spectroscopy, transmission electron microscopy, powder X-ray diffraction and UV-Vis-NIR absorption spectra. The biocompatibility and photothermal effect were evaluated by the CCK-8 assay. The photothermal cytotoxicity of AuNR@MIL-100 in vivo was assessed by monitoring tumor growth. The tumor tissues were investigated by Hema-toxylin and eosin (H&E) and terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) to further analyse photothermal effect. The MRI of AuNR@MIL-100 was analysed in vivo.

Conference:

Presenting Author:

Authors: He J,

Keywords: Magnetic resonance imaging, Pancreatic neuroendocrine tumor, Photothermal therapy, Gold nanorods@iron-based metal-organic framework,