Multiregion Analysis Reveal Evolutionary Patterns and a Chromosomal Instability Signature in Pancreatic Neuroendocrine Tumours

#1523

Introduction: Pancreatic neuroendocrine tumors (PNETs) are potentially lethal diseases that show variable degrees of proliferation and invasiveness. Although genetic subgroups have been suggested to give prognostic information the impact of clonal evolution to the development and outcome of PNETs remains unexplored.

Aim(s): To elucidate the aberrations in PNET genomes and their role in tumourigenesis and metastatic spread.

Materials and methods: An integrative analysis of mutational spectra and copy number variations in 169 PNET samples from 94 patients.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Crona J

Authors: Crona J, Backman S, Kugelberg J, Maharjan R, Björklund P,

Keywords: Cancer evolution, Molecular genetics, Neuroendocrine Tumor,