Myelophthisis as an end-stage outcome of rare metastases in neuroendocrine tumors – A dual case report

#3677

Introduction: Intra-abdominal Neuroendocrine Tumors (NETs) usually metastasize to regional lymph nodes, liver, and bone. Myelophthisis (MPT) is the destruction of the medullary microenvironment due to the tumoral invasion of the trabecular space, altering normal hematopoiesis; it’s frequently caused by metastasis of breast, prostate, and lung adenocarcinomas, and neuroblastoma. MPT due to NET is an unrecognized phenomenon with few cases reported, almost exclusively in poorly differentiated NETs.

Aim(s): To report two cases of well-differentiated NET patients with MPT and a literature review.

Materials and methods: A retrospective review was made of the medical records of the Fundación Santa Fe de Bogotá, Colombia, from January 2001 to October 2022. We quantified the incidence of NETs by pathology records. Clinical, radiological, pathological, surgical procedures, and therapeutic data were collected.

Conference:

Presenting Author:

Authors: González Devia D, Aldana-Gómez L, Segovia Gómez J, Ortiz-Santacruz C, Mejía-Arango M,

Keywords: Neuroendocrine Tumor, Myelophthisis, Colon tumor, Prostate tumor, End-stage,