N-terminal pro-brain natriuretic peptide and chromogranin A as biomarkers for detection of carcinoid heart disease

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Introduction: Carcinoid heart disease (CHD) is a serious complication for patients with neuroendocrine tumors (NETs), and early detection is crucial.

Aim(s): We aimed to investigate if N-terminal pro-brain natriuretic peptide (NT-proBNP), Chromogranin A (CgA), and 5-Hydroxyindoleacetic acid (5-HIAA) could be used as a screening tool for detection of CHD.

Materials and methods: We prospectively included patients with disseminated small intestinal NETs (SI-NETs) and performed trans-thoracic echocardiography (TTE), questionnaires, and biochemical assessment of NT-proBNP, CgA, and 5-HIAA. The presence and severity of CHD was assessed using a scoring system based on echocardiographic characteristics.

Conference:

Presenting Author: Lau T

Authors: Lau T, Johnson K, Oksjoki R, Baunwall S, Villadsen G,

Keywords: carcinoid heart disease, probnp, 5-hiaa, cga, biomarker,