Near-complete regression of liver metastatic lesions in a patient with advanced pancreatic gastrinoma in response to somatostatin analogue therapy following cytoreductive surgery

#148

Introduction: Although the majority of pancreatic NETs present with hepatic metastases, surgery with curative intent should be the first consideration. Cytoreductive surgery by resection of primary and secondary deposits may be of value in achieving local or endocrine symptoms control.

Aim(s): We describe here a near complete response to treatment with somatostatin analogues with reduction in vascularity and size of tumor bulk, in a patient who underwent initial surgery for metastatic pancreatic NET following primary resection.

Materials and methods: A 23-year-old woman presented with a 2-year history of watery diarrhoea and three weeks of epigastric pain and vomiting. CT showed a 6 x 5 cm enhancing mass in the head of the pancreas with metastatic disease in both lobes of the liver. Plasma gastrin was at 210pmol/L (ref 0-40 pmol/L) and chromogranin A was at 182pmol/L (ref

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Dworakowska D

Authors: Dworakowska D, Whyte M, Kane P, Patel A, Aylwin S,

Keywords: somatostatin analogues, metastatic pancreatic gastrinoma,