Network pharmacology reveal the mechanism of Cordycepin and neuroendocrine tumors
#4014
Introduction: Patients with advanced neuroendocrine tumors (NETs) have few treatment options and poor prognosis. Cordycepin is a natural compound originally isolated from Cordyceps militaris. It has the potential to treat cancer by regulating multiple cellular signaling pathways. However, its anticancer effect and pharmacological mechanism in NETs have not been clarified.
Aim(s): We aimed to reveal the potential mechanism of Cordycepin treatment of NETs through network pharmacology methods.
Materials and methods: The potential targets of action of Cordycepin were predicted by Swiss Target Prediction. The targets of NETs were obtained by the databases of Gene Card. Common targets of cordycepin and NETs were collected through online tool Venny 2.1. Protein-protein interaction (PPI) network was obtained by String database. GO and KEGG pathway enrichment analysis was performed on drug-disease targets.
Conference:
Presenting Author:
Authors: Liu M, Yan L, Tang Q,
Keywords: Cordycepin, neuroendocrine tumor, network pharmacology, enrichment analysis, Chinese medicine,
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