Novel patient-derived tumor organoid models reveal growth-factor dependencies in neuroendocrine tumors and serve as a platform for neuroendocrine cancer research

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Introduction: Neuroendocrine neoplasms (NENs) comprise neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs). While NETs are well-differentiated and progress slowly, NECs are poorly differentiated and have a poor prognosis. Irrespective of subtype, treatment options for patients with unresectable, relapsed, or metastasized NENs are limited, in part due to lack of accurate models to study these diseases.

Aim(s): We applied the organoid culture system to develop accurate in vitro models of NENs.

Materials and methods: Using a completely defined growth medium, we developed the first described patient-derived tumor organoids (PDTOs) from low-grade pulmonary NETs. We also established PDTOs from large cell NECs (LCNECs).

Conference:

Presenting Author: Dayton T

Authors: Dayton T, Alcala N, Moonen L, van den Berg J, Buikhuisen W,

Keywords: patient derived tumor organoids, pulmonary NET, LCNEC, growth-factor dependency,