Ovriectomy

#789

Introduction: Bilateral OVX in female rats cause neurodegeneration in the nervous system of rodents and imitates systemic disorders in postmenopausal women. Synaptic modulation by estrogen is essential to understanding the molecular mechanisms of estrogen replacement therapy.

Aim(s): To determine the action of Sinestrol on rats’ hippocampal synaptic transmission, plasticity and cell survival in condition of bilateral OVX. Electrophysiological and morphohistochemical (by revealing Са2+-dependent acid phosphatase) studies by extracellular recording of hippocampal single-neuronal spike activity under high-frequency stimulation (HFS) of entorhinal cortex (EC) were performed on: 1) intact Albino rats, 2) after 8 weeks of OVX (placebo-control), 3) after 8 weeks of OVX (after 3 weeks i/m injection of Sinestrol- 0.1ml 2%).

Materials and methods: Electrophysiological and morphohistochemical (by revealing Са2+-dependent acid phosphatase) studies.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Simonyan K

Authors: Simonyan K,

Keywords: Sinestrol, hippocamp, synaptic activity, phosphatase activity,