Oxaliplatin-based Chemotherapy in Advanced Neuroendocrine Tumors: Clinical Outcomes and Preliminary Correlation with Biological Factors


Introduction: The role of chemotherapy in low/intermediate grade neuroendocrine tumors (NETs) is still debated.

Aim(s): To evaluate activity and toxicity of oxaliplatin-based chemotherapy in patients with advanced NETs in an Italian multicenter “real world” retrospective study.

Materials and methods: Clinical records from 5 referral centers were reviewed. Disease control rate corresponding to PR+SD (partial response + stable disease), progression free survival (PFS), overall survival (OS) and toxicity were calculated. Ki67 labeling-index, grade of differentiation and excision-repair-cross-complementing group-1 (ERCC-1) were analyzed in tissue tumor samples.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Spada F

Authors: Spada F, Antonuzzo L, Marconcini R, Radice D, Antonuzzo A,

Keywords: Oxaliplatin, NETs,

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