Palliative CT Brachytherapy in Hepatic Metastatic NET

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Introduction: Hepatic metastases of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) may induce prognosis relevant complications in an otherwise stable systemic disease after resection of the primary.

Aim(s): To determine the period by which the CT guided high-dose-rate brachytherapy (HDR-BT) of rapidly growing liver metastases can delay the onset of palliative systemic therapy with otherwise stable disease course.

Materials and methods: Retrospective, monocentric observational study of 23 patients with a total of 37 CT-guided HDR brachytherapy (HDR-BT) sessions were evaluated for the delay of a systemic therapy escalation by individual, highly selective HD-BRT in oligotopic hepatic progression. Additional endpoints were local tumor control (LTC), progression-free survival (PFS) and overall survival (OS). HDR-BT was initiated by a ENETS multidisciplinary team (MDT) meeting vote.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Jann H

Authors: Feldhaus F, Jann H, Jonczyk M, Boening G, Wieners G,

Keywords: brachytherapy, afterloading, hepatic metastases, local tumor ablation, local tumor control,