Pancreatic stellate cells promote tumorigenesis and progression of pancreatic neuroendocrine tumours through SERPINE2 and KCNA5

#4476

Introduction: Pancreatic stellate cells (PSC) are stromal cells in the pancreas that play a significant role in pancreatic pathology. Nevertheless, few studies have explored the significance of PSC in pancreatic neuroendocrine tumours (panNET). Their contribution to the fibrotic responses in panNET remains poorly understood. How PSC promote tumorigenesis and differentiation in panNET after being activated to myofibroblasts or cancer-associated fibroblasts (CAF) has not been studied.

Aim(s): To investigate the interaction between PSC and NET cells.

Materials and methods: (1) Identification of key genes involved in the tumorigenesis and progression of panNET by comparing transcriptome and single-cell data from panNET tissues and adjacent normal pancreatic tissues. (2) Analysis of specific gene expression in panNET cells cultured in conditioned medium derived from PSC. (3) Analysis of the mechanism underlying the regulation exerted by PSC on panNET using biological tools.

Conference:

Presenting Author: Tang Q

Authors: Liu J, Li X, Bai J, Tang Q,

Keywords: caf, stellate cell, pan NET, Oncogenes,