PANDORA-2 protocol - Intervention study to improve quality of life in patients with small (≤2 cm) non-functional pancreatic neuroendocrine tumors

#3482

Introduction: Current guidelines changed the treatment strategy for small (≤2cm) non-functioning pancreatic neuroendocrine tumors (NF-pNET) from tumor resection to an active surveillance strategy. The previous PANDORA-1 (2021) study showed excellent clinical outcomes after a median follow-up of 17 months, where 89% of patients had pNETs without any tumor growth and only 3% of patients had tumor growth leading to a resection. Despite these results, the quality of life (QoL) was decreased at baseline and during follow-up. Furthermore, there was suboptimal adherence to the advised surveillance protocol.

Aim(s): The current PANDORA-2 study strives to improve the QoL for patients with small (≤2 cm) non-functional pancreatic neuroendocrine tumors by reducing the burden of the previous PANDORA-1 protocol and by introducing a supportive care intervention.

Materials and methods: A nation-wide multicenter intervention study. Patients follow a reduced intensity protocol with 6 moments of radiological imaging instead of 13, spread out over 10 years. The diagnosis will be made using both a 68Ga-DOTATATE-scan and a CT- or MRI-scan. At 3 months patients undergo endoscopic ultrasonography with fine-needle biopsy, to confirm the size and diagnosis, as well as to determine tumor grade. In the second half of this study, patients will also follow an additional supportive care intervention. Finally, a cost-benefit analysis will be performed.

Conference:

Presenting Author: Chen J

Authors: Chen J, Heidsma C, Engelsman A, Nieveen van Dijkum E,

Keywords: neuroendocrine, pancreatic, quality of life, ≤2 cm, non-functional, protocol,