Paraneoplastic cerebellar degeneration relates to lung neuroendocrine tumour

#4472

Introduction: Neurological Paraneoplastic syndromes related to cancer are infrequently, <1/10.000 patients with solid and hematologic malignancies; neurological phenotypes and neural autoantibody (Ab) profiles are heterogeneous. The frequency in Neuroendocrine Tumour (NET) ranges from 0.01% to 8%, most frequent in small cell lung carcinoma. Paraneoplastic cerebellar degeneration (PCD) leads to loss of Purkinje cells in the cerebellum, reporting ataxic gait, dysarthria, and nystagmus; the prognosis is variable, anti-CARP VIII is associated with severe cognitive impairment; only 4 cases have been reported.

Aim(s): To report the association of CARP VIII Ab with PCD in well-differentiated lung NET.

Materials and methods: A 70-year-old woman reported progressive cerebellar ataxia of 1 month's duration; cerebral oligodendroglioma was resected without sequelae at age 46/47 years. Baseline MRI without ischemic or neoplastic lesions, cerebrospinal fluid (CSF) was inflammatory (atypical T lymphocytes, elevated proteins).

Conference:

Presenting Author:

Authors: González Devia D, Roa Culma L, Martínez Rubio C, Zafra Sierra M, Cañon Solano D,

Keywords: Paraneoplastic Syndrome, Paraneoplastic Cerebellar Degeneration, Neuroendocrine Tumour, Lung Neuroendocrine Tumour, CARP 8 antibody,