Paraneoplastic Neurological Syndrome in a Patient with a Pancreatic Well-Differentiated Endocrine Tumor

#506

Introduction: Few studies report the association of neurological syndromes with a carcinoid, the majority being small-cell lung cancer.

Aim(s): In May 2011, a 61-year-old man with controlled diabetes started noticing an imbalance that progressed over weeks. He complained of consistent weight loss over a few months. Upon examination, he had symptoms of acute cerebellar degeneration: dysdiadochokinesia, mild dysarthria, dizziness, vertigo and clear ataxic gait.

Materials and methods: Lumbar puncture and nerve conduction study were within normal limits. Search for nervous system tumor localization (MRI and CT scan) was negative. Patient sera was negative for antineuronal auto-antibodies. Abdominal CT scan revealed a large pancreatic mass with multiple liver metastases. A liver biopsy showed a well-differentiated neuroendocrine tumor (WDNET), Ki-67 5%. Serum Chromogranin A was supranormal and 111In-octreotide scintigraphy resulted positive.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Brizzi M, Ferrero A, Ottone A, Bellini E, Bitossi R,

Keywords: paraneoplastic syndrome,