Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma
Introduction: Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a poorly understood disease with limited treatment options. Due to its low incidence and wide tissue distribution few representative preclinical models are available
Aim(s): Here, we present the potential of tumor organoids, three dimensional cultures of tumor cells, to model GEP-NEC
Materials and methods: We established and characterized three GEP-NEC organoid lines, originating from the stomach, colon and ampulla of Vater
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Tesselaar M
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