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Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma


Introduction: Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a poorly understood disease with limited treatment options. Due to its low incidence and wide tissue distribution few representative preclinical models are available

Aim(s): Here, we present the potential of tumor organoids, three dimensional cultures of tumor cells, to model GEP-NEC

Materials and methods: We established and characterized three GEP-NEC organoid lines, originating from the stomach, colon and ampulla of Vater

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Tesselaar M

Authors: Dijkstra K, van den Berg J, Weber F, van de Haar J, Velds A,

Keywords: organoids, gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC), disease modeling, pre-clinical models,

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