PD-L1 Expression and Quantitative Assessment of Tumor-Infiltrating T Cell Subsets in Carcinoid Tumors and Large Cell Neuroendocrine Carcinomas of the Lung

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Introduction: Little is known about the expression of PD-L1 an the immune infiltrate in neuroendocrine neoplasms of the lung.

Aim(s): To assess the immune environment in pulmonary carcinoids and large-cell neuroendocrine carcinoma (LCNEC) of the lung.

Materials and methods: Sixty-five resected lung NE tumors (49 typical carcinoids (TC), 5 atypical carcinoids (AC) and 11 LCNEC) were studied. Automated immunohistochemistry for PD-L1 (clone E1L3N), CD8 (clone SP16) and FoxP3 (clone SP97) was performed on whole tissue sections from formalin fixed paraffin-embedded tumor samples. Densities of CD8+ and FoxP3+ cells were assessed at the invasion margin (InvM) and in the tumor center (TumC) by image analysis using Definiens Developer XD software under the supervision of a pathologist.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Julien H

Authors: Kossai M, Hadoux J, Louvet E, Sullivan I, Thomas de Montpreville V,

Keywords: PD-L1, lung, neuroendocrine, immune infiltrate.,